The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1.

Abstract : The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd), was isolated from a human Chromosome (Chr) 1 cosmid library (LLNL, UK HGMP). The gene spans 11 kilobases and contains nine exons and eight introns. Four alternative transcript variants were observed in activated T cells. Three single-nucleotide polymorphisms were identified within intron 2. A variable number of GA repeats was found at position -340 from the first coding ATG. Linkage analysis using this marker in eight CEPH families showed that the SH2D2A gene is located close to the D1S2624 marker on Chr 1q21-1q22. Physical mapping of a PAC and BAC contig containing the CD1 gene cluster telomeric to D1S2624 failed to identify a clone harboring the SH2D2A gene. Thus the SH2D2A gene is located centromeric to the CD1 gene cluster on Chr 1.
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Article dans une revue
Immunogenetics, Springer Verlag, 2000, 51 (3), pp.179-85
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Contributeur : Gilles Vergnaud <>
Soumis le : mercredi 3 juin 2015 - 18:29:36
Dernière modification le : jeudi 11 janvier 2018 - 06:19:24

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  • HAL Id : hal-01159807, version 1
  • PUBMED : 10752626

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K Z Dai, Gilles Vergnaud, A Ando, H Inoko, A Spurkland. The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1.. Immunogenetics, Springer Verlag, 2000, 51 (3), pp.179-85. 〈hal-01159807〉

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