Genetic mapping of three human homologues of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG.

H Blanché; L G Wright; Gilles Vergnaud; B De Gouyon; V Lauthier; L M Silver; J Dausset; H M Cann; R S Spielman

Genetic mapping of three human homologues of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG.

H Blanché ¹ L G Wright Gilles Vergnaud ^{2, 3} B De Gouyon V Lauthier L M Silver J Dausset ⁴ H M Cann R S Spielman

1 CEPH - Centre d'Etude du Polymorphisme Humain

2 IGM - Institut de génétique et microbiologie [Orsay]

3 Univ. Paris-Saclay, ENSTA ParisTech - École Nationale Supérieure de Techniques Avancées

4 SRHI - UMR E05 - Service de Recherche en Hémato-Immunologie

Abstract : Human homologues of mouse t-complex genes have been cloned and localized physically to chromosome 6p or 6q. TCP1, TCP10, and PLG are human homologues of genes located in the proximal portion of the t-complex on mouse chromosome 17. We present here results of genetic mapping of these human t-complex homologues previously localized to 6q25-q27, 6q21-q27, and 6q26-q27, respectively, by physical techniques. TCP1 and PLG do not recombine with each other and are separated from TCP10 by about 15 cM, while the corresponding mouse genes are no more than 4 cM apart. Genetic mapping with markers well localized cytogenetically places TCP1 and PLG proximal to TCP10 and localizes the latter to the cytogenetic band 6q27. It is likely that the organization of human t-complex homologues on 6q is similar to that of t haplotypes rather than that of wildtype murine chromosome 17.

Type de document :

Article dans une revue

Genomics, Elsevier, 1992, 12 (4), pp.826-8

Domaine :

Sciences du Vivant [q-bio]

Liste complète des métadonnées

https://hal-ensta.archives-ouvertes.fr/hal-01160689
Contributeur : Gilles Vergnaud <>
Soumis le : samedi 6 juin 2015 - 17:25:44
Dernière modification le : lundi 18 février 2019 - 10:52:02

Genetic mapping of three human homologues of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG.

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Genetic mapping of three human homologues of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG.

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