Two highly polymorphic minisatellites from the pseudoautosomal region of the human sex chromosomes.

Marie-Christine Simmler (1) , Christophe Johnsson (1) , Christine Petit (1) , François Rouyer (1) , Gilles Vergnaud (2, 3) , Jean Weissenbach (1)

1 Biologie moléculaire des infections virales et cancérologie [Paris]
2 IGM - Institut de génétique et microbiologie [Orsay]
3 ENSTA Paris - École Nationale Supérieure de Techniques Avancées

Two pseudoautosomal loci DXYS15 and DXYS17 from the pairing region of the human sex chromosomes display a high variability with at least eight alleles each. The structural elements responsible for the polymorphisms have been isolated and sequenced. In both cases the variations result from DNA rearrangements occurring in tandemly repeated sequences (minisatellites) of 21-29 nucleotides for DXYS15 and 28-33 nucleotides for DXYS17. At reduced stringency, the DXYS15 minisatellite detects other hypervariable sequences located in other parts of the genome and hence represents a new family of minisatellites. In contrast to most other known hypervariable families, the DXYS15 hypervariable sequence displays a very high AT content.

Domaines: Sciences du Vivant [q-bio]

Marie-Christine Simmler, Christophe Johnsson, Christine Petit, François Rouyer, Gilles Vergnaud, et al.. Two highly polymorphic minisatellites from the pseudoautosomal region of the human sex chromosomes.. EMBO Journal, 1987, 6 (4), pp.963-9. ⟨10.1002/j.1460-2075.1987.tb04846.x⟩. ⟨hal-01160706⟩