Effects of reactive oxygen species on metabolism monitored by longitudinal 1 H single voxel MRS follow-up in patients with mitochondrial disease or cerebral tumors

Abstract : Free radicals, or Reactive Oxygen Species (ROS), have an effect on energy and glycolytic metabolism, mitochondrial function, lipid metabolism, necrosis and apoptosis, cell proliferation, and infiltration. These changes could be monitored longitudinally (every 4 months over 6 years) in humans with glial brain tumors (low and high grade) after therapy, using conventional magnetic resonance imaging (MRI) and spectroscopy (MRS) and MR perfusion. Some examples of early clinical data from longitudinal follow-up monitoring in humans of energy and glycolytic metabolism, lipid metabolism, necrosis, proliferation, and infiltration measured by conventional MRI, MRS and perfusion, and positron emission tomography (PET) are shown in glial brain tumors after therapy. Despite the difficulty, the variability and unknown factors, these repeated measurements give us a better insight into the nature of the different processes, tumor progression and therapeutic response.
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COST Chemistry CM0603-MELUSYN Joint Meeting Damages Induced in Biomolecules by Low and High Energy Radiations, Mar 2010, Paris, France. 261, 2011, 〈10.1088/1742-6596/261/1/012011〉
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Contributeur : Pierre Zaparucha <>
Soumis le : jeudi 1 décembre 2016 - 15:24:14
Dernière modification le : mardi 5 juin 2018 - 10:14:42

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J M Constans, S Collet, S Guillamo, G Hossu, S Lacombe, et al.. Effects of reactive oxygen species on metabolism monitored by longitudinal 1 H single voxel MRS follow-up in patients with mitochondrial disease or cerebral tumors. COST Chemistry CM0603-MELUSYN Joint Meeting Damages Induced in Biomolecules by Low and High Energy Radiations, Mar 2010, Paris, France. 261, 2011, 〈10.1088/1742-6596/261/1/012011〉. 〈hal-01406778〉

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